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Injection moulding machine prototype
Cikryt, Adam ; Jirgl, Miroslav (referee) ; Arm, Jakub (advisor)
This work deals with the design of a prototype injection molding machine for the company Elzaco s.r.o. The work includes theoretical analysis which breaks down injection molding machine into individual components and describes their functionality and their important parameters. Based on the analysis and determination of critical parameters of the injection molding machine, a detailed model of the injection molding machine is created. There are also requirements for electrical components such as motors, power supplies, heaters, temperature sensors, control electronics. The method of controlling such a machine is also discussed.
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Optimization of Material Plastification Process
Šeniglová, Hana ; Krpoun, Karel (referee) ; Pantělejev, Libor (advisor)
This bachelor´s thesis deal with the optimization of the process of material plastification. The purpose of the thesis is to devise feasible parameters of a injection molding machine. The goal was achieved by the „Design of Experiments“ method. The necessary measurements were taken on the sample, a filter fuel tank, which was provided by the company Robert Bosch České Budějovice. Each measurements are described in the bachelor´s thesis. The results are summarized and evaluated in the Minitab software used for optimal parameters settings of the production process.
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Innovative wood-based materials
Buriánek, Vlastimil ; Brožovský, Jiří (referee) ; Vaněrek, Jan (advisor)
This bachelor’s thesis deals with the issue of optimizing the modification process for plywood boards. Optimization consists mainly in evaluating different densification methods with different parameters of plasticization and stabilization. Psychical parameters (bulk density, swelling, water absorption) and strength parameters (bending strength, modulus of elasticity) of modified plates were chosen for the evaluation parameters. The practical part involved the verification of two thickening treatments on birch plywood.
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Rozměrová stabilizace lisovaných dřevěných dílců
Karásek, Lukáš
This diploma thesis deals with wood plasticization using microwave (MW) radiation for wood densification purposes. In this work, the literary sources of the investigated issue were summarized. The experiment was carried out on test samples of white poplar (Populus alba) with dimensions of 190 x 40 x 30 mm. Microwave plasticization was carried out by passing through a microwave laboratory line at a power of 1.5 kW and a conveyor speed of 0.1 m/min. After plasticization, the test samples were compacted in compression molds by a press by 50%. The compacted test samples were stabilized in compression molds at a temperature of 103°C for 7 days. Using heat modification at 180°C and 200°C improved moisture resistance and reduced swelling. The samples were subjected to density profile analysis to evaluate the plasticization quality.
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Analýza vad vzniklých při strojním ohýbání bukových hranolků
Ondroušková, Jitka
This thesis analyzes the conditions and parameters entering the selected operations while bending beech scantlings. Then it deals with the requirements for the properties and quality of the material. The analysis was performed on the plasticization steaming operation and the bending operation on the bending machine with rotating core. It also describes a clarifies the effect of selected factors on the origin and nature of the defects. The measurements and observations were carried out at the factory Ton plc. The general conclusions confronted with the literature concerned with the topic in the past were inferred in the end of the thesis.
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Innovative wood-based materials
Buriánek, Vlastimil ; Brožovský, Jiří (referee) ; Vaněrek, Jan (advisor)
This bachelor’s thesis deals with the issue of optimizing the modification process for plywood boards. Optimization consists mainly in evaluating different densification methods with different parameters of plasticization and stabilization. Psychical parameters (bulk density, swelling, water absorption) and strength parameters (bending strength, modulus of elasticity) of modified plates were chosen for the evaluation parameters. The practical part involved the verification of two thickening treatments on birch plywood.
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Influence of formulation factors on the characteristics of terbinafine loaded nanoparticles.
Barák, Vlastimil ; Šnejdrová, Eva (advisor) ; Dittrich, Milan (referee)
CHARLES UNIVERSITY FACULTY OF PHARMACY IN HRADEC KRÁLOVÉ DEPARTMENT OF PHARMACEUTICAL TECHNOLOGY Author: Vlastimil Barák Title of Diploma thesis The influence of formulation factors on the characteristics of terbinafine loaded nanoparticles Supervisor: PharmDr. Eva Šnejdrová, Ph.D. Consultant: Mgr. Juraj Martiška The diploma thesis is focused on biodegradable polymer nanoparticles loaded by terbinafine based on the copolymer of glycolic and lactic acid branched on polyacrylic acid. The nanoprecipitation method was employed, and the influence of formulation factors on nanoparticle characteristics was studied. The following formulation factors were the concentration of the polymer, the amount of terbinafine, and the concentration of surfactant. Nanoparticles of 120 nm to 300 nm were obtained depending on the preparation conditions. The nanoparticle polydispersity was in all cases from 0.080 to 0.230. The prepared nanoparticles were stable, as evidenced by zeta potential values above 38 mV. A positive zeta potential is desirable for dermal and mucosal adhesion in the topical and ocular application of nanoparticles with terbinafine. The amount of polymer used to form nanoparticles has the greatest effect on particle size. With increasing polyester concentration in the internal phase, the size of the...
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Terbinafine-loaded biodegradable polymeric systems for topical administration
Pokorná, Tereza ; Šnejdrová, Eva (advisor) ; Dittrich, Milan (referee)
CHARLES UNIVERSITY FACULTY OF PHARMACY IN HRADEC KRÁLOVÉ DEPARTMENT OF PHARMACEUTICAL TECHNOLOGY Author: Tereza Pokorná Title of Diploma thesis Terbinafine-loaded biodegradable polymeric systems for topical administration Supervisor: PharmDr. Eva Šnejdrová, Ph.D. In the diploma thesis the released properties of solid dispersions with terbinafine, based on polyesters of D,L-lactic acid and glycol acid, branched with pentaerythritol and tripentaerythritol are studied. The theoretical part deals with solid dispersions, their classification and methods of preparation, methods of drug dissolution testing, properties, effect, use of terbinafine and preparations containing terbinafine. In the experimental part, solid dispersions were prepared by the melting method. The drug was incorporated into the polyester in the form of a hydrochloride or a base in a concentration of 10 % or 20 %. Some systems were plasticized with 30% triethyl citrate. Thin layers were formulated from solid dispersions, and drug dissolution tests were performed on phosphate buffer pH 7.4 at 37 řC. Assay of terbinafine released was performed spectrophotometrically at 223 nm and ultra-high performance liquid chromatography. Based on the results of this diploma thesis, it can be clearly stated that the suitable carrier of terbinafine...
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Acyclovir release from mucoadhesive matrices
Šišáková, Lenka ; Šnejdrová, Eva (advisor) ; Dittrich, Milan (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Technology Student: Lenka Šišáková Supervisor of Diploma thesis: PharmDr. Eva Šnejdrová, Ph.D. Title of Diploma thesis: Aciclovir release from mucoadhesive matrices The aim of this diploma thesis was the study of the mucoadhesive parameters of plasticized oligoester of lactic acid and glycolic acid and 3% mannitol as a branching monomer. Knowledge of dissolution testing of drug release from dosage form, principal theories and mechanisms of mucoadhesion and mucoadhesion testing of adhesive formulation is described in theoretical part. Matrices formed from terpolymer of D,L-lactic acid, glycolic acid branched with mannitol and 5 % aciclovir were examined in the experimental part. Triethylcitrate (TEC), ethylpyruvate (EP), methylsalicylate (MS) and ethylsalicylate (ES) were used as plasticizers. Dissolution test has been done. Hydrated mucin from porcine stomach was used as a base. Phosphate-citrate buffer pH 7.4 was used as a dissolution medium. Dissolution was defined as a quantity of released aciclovir in to the dissolution medium after 15, 30, 60 and 90 minutes. The quantity of the released aciclovir was defined by a spectrophotometry. In 90 minutes was released 43 % of aciclovir from the matrice...
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Influence of formulation factors on the characteristics of terbinafine loaded nanoparticles.
Barák, Vlastimil ; Šnejdrová, Eva (advisor) ; Dittrich, Milan (referee)
CHARLES UNIVERSITY FACULTY OF PHARMACY IN HRADEC KRÁLOVÉ DEPARTMENT OF PHARMACEUTICAL TECHNOLOGY Author: Vlastimil Barák Title of Diploma thesis The influence of formulation factors on the characteristics of terbinafine loaded nanoparticles Supervisor: PharmDr. Eva Šnejdrová, Ph.D. Consultant: Mgr. Juraj Martiška The diploma thesis is focused on biodegradable polymer nanoparticles loaded by terbinafine based on the copolymer of glycolic and lactic acid branched on polyacrylic acid. The nanoprecipitation method was employed, and the influence of formulation factors on nanoparticle characteristics was studied. The following formulation factors were the concentration of the polymer, the amount of terbinafine, and the concentration of surfactant. Nanoparticles of 120 nm to 300 nm were obtained depending on the preparation conditions. The nanoparticle polydispersity was in all cases from 0.080 to 0.230. The prepared nanoparticles were stable, as evidenced by zeta potential values above 38 mV. A positive zeta potential is desirable for dermal and mucosal adhesion in the topical and ocular application of nanoparticles with terbinafine. The amount of polymer used to form nanoparticles has the greatest effect on particle size. With increasing polyester concentration in the internal phase, the size of the...
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